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Multifocal granular cell tumors of the gastrointestinal tract: Immunohistochemical findings compared with those of solitary tumors
Author(s) -
Mitomi Hiroyuki,
Matsumoto Yutaka,
Mori Akio,
Arai Nobuyasu,
Ishii Keita,
Tanabe Satoshi,
Kobayashi Kiyonori,
Sada Miwa,
Mieno Hiroyoshi
Publication year - 2004
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2004.01579.x
Subject(s) - immunohistochemistry , pathology , esophagus , gastrointestinal tract , stomach , cyclin d1 , granular cell , medicine , anatomy , cancer , gastroenterology , cell cycle , central nervous system
Granular cell tumors (GCT) are infrequently found in the gastrointestinal tract (GIT), and only four previous reports have described lesions occurring simultaneously in different sites. The present case of 11 GCT, located in the esophagus, stomach, colon and pericolic adipose tissue, occurred in a 50‐year‐old Japanese woman. All GCT appeared histologically benign and there was no sign of recurrence at 3 years after surgery. Immunohistochemical analysis and comparison between this case of multifocal GCT and six cases of solitary benign GCT of the GIT, which were taken from the files of the Department of Pathology at Kitasato University (1986–2000), demonstrated the follow‐ing: (1) all diffusely expressed S‐100, DCC and bcl‐2, and (2) median labeling indices for Ki‐67, cyclin D1, p53 (Pab1801), and p21 WAF1/ CIP1 of 4%, 24%, 1% and 28%, respectively, for the multifocal tumors, and 3.5%, 23%, 1% and 29%, respectively, for the solitary lesions, with no significant difference between the two groups. Thus, the expression of cyclin D1 and p21 WAF1/ CIP1 may be involved in the tumorigenesis of both types of GCT. The present case emphasizes the need to evaluate the entire GIT when a single GCT is identified. Multifocal lesions should be treated conservatively by local excision because, as with the solitary tumors, they exhibit a benign biological behavior, consistent with their low Ki‐67 immunoreactivity.