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Giant cell tumor of bone: A clinicopathologic study of prognostic factors
Author(s) -
Masui Fumiaki,
Ushigome Shinichiro,
Fujii Katsuyuki
Publication year - 1998
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1998.tb03973.x
Subject(s) - medicine , lung , metastasis , radiography , grading (engineering) , giant cell tumor of bone , stromal cell , surgery , bone metastasis , giant cell , pathology , radiology , cancer , biology , ecology
Forty‐seven cases of giant cell tumor of bone were clini‐copathologically reviewed to determine any useful prognostic factors. Disease recurred In 11 cases. Eight of these cases had initially been treated with lntracapsular piecemeal excision and three cases had been treated with wide excision. Nine of the 11 cases were classified as Grade III, two cases as Grade II, and one case as Grade II + fracture according to Campanacci's radiographic grading system. lntracapsularly excised cases had a high recurrence rate (47.1%). Metastasis to the lung occurred in three cases, each of which had been classified as Grade III. Although the radiographic Grade did not correlate wlth the rate of lung metastasis or recurrence, cases that metastasized to the lung or recurred tended to be radiographically aggressive. Disease recurred in eight of 24 Grade III cases; but in only two of 12 Grade II cases, in one of five Grade II + fracture cases, and none of six Grade I cases. p53 Was expressed by mononuclear stromal cells in SIX cases. Disease recurred In four and lung metastasis occurred In three of these cases. p53 Expression correlated wlth rates of lung metastasis and recurrence. R was concluded that cases in which p53 is expressed have a high potential for lung metastasis and recurrence.