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Expression of cytotoxic molecule TIA‐1 in malignant lymphomas mimicking fulminant hepatitis
Author(s) -
Sadahira Yoshito,
Ohmoto Kenji,
Yamamoto Shinichiroh,
Nishihara Hiroji,
Wads Hideho,
Yawata Yoshihito,
Manabe Toshiaki
Publication year - 1998
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1998.tb03970.x
Subject(s) - cytotoxic t cell , lymphoma , pathology , fulminant hepatic failure , medicine , t cell lymphoma , fulminant , fulminant hepatitis , cd8 , hepatitis , immunology , biology , antigen , transplantation , liver transplantation , biochemistry , in vitro
Involvement of malignant lymphoma in the liver inducing fuiminant hepatic failure has rarely been reported. There fore, a close association between some lymphoma types with severe liver damage and the mechanism underlying the liver damage is intriguing. Three malignant lymphoma cases, which were clinically diagnosed as fulminant hepatitis, were collected from the autopsy records of Kawasaki Medical School (Kurashiki, Japan). All three cases were characterized by the presence of hepatosplenomegaly without superficial lymph node swelling, high elevation of transaminase and lactate dehydrogenase (LDH; especially LDH‐2), and a quite aggressive clinical course. Immuno‐histochemlcally, the tumor cells in all three cases were positive for T cell intracellular antlgen VIA‐l), which is a cytolytic protein in cytotoxic T and natural klller (NK) cells. The lymphomas were CD8 + perlpheral T cell lymphoma (case l), CD56 + T/NK cell lymphoma (case 2), and T cell lymphoma in a patient with mosquito hypersensitivity (case 3). Epstein‐Barr virus infection was demonstrated on the tumor cells of cases 2 and 3 using an in situ hybridization method and those cases showed high titers of serum interferon‐γ and Fas. Frequent apoptosis of liver cells, where the lymphoma cells had infiltrated, was revealed by a terminal deoxyribosyl transferase‐mediated deoxyuridine nick end‐labeling (TUNEL) method. The findings in this study suggest that fulminant hepatic injury is closely associated with cytotoxic molecule TIA‐1 expression of the lymphoma cells and that some specific mechanism may be involved In liver damage.