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Cystic renal cell carcinoma: Arose as a simple cyst, recurred repeatedly as a multicystic mass and finally presented as a solid mass
Author(s) -
Shishikura Yuri,
Furusato Masakuni,
Aizawa Shigeo
Publication year - 1998
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1998.tb03960.x
Subject(s) - pathology , cyst , renal cell carcinoma , nephrectomy , differential diagnosis , biology , kidney , polyploid , multicystic dysplastic kidney , clear cell carcinoma , ploidy , pathological , carcinoma , choledochal cysts , anatomy , medicine , urinary system , biochemistry , gene , endocrinology
An unusual case of cystic renal cell carcinoma in a 70‐year‐old Japanese male is reported. He had had a simple renal cyst removed 1 year ago. On presentation the right kidney was surrounded by multiple translucent cysts, which varied in size from 1 to 50 mm. The cyst walls were lined by slngle‐layered cuboidal epithelium. The differential diagnosis included cystic mesothelioma, cystic lymphangioma and multlcystic dysplastic kidney. An immunohistochemical and ultrastructural study and flow cytometric analysis of DNA ploldy were performed. The tumor was dlfferentiated to such an extent that it was difficult to diagnose as carcinoma; however, it recurred repeatedly. Three and a half years after initial presentation the tumor had invaded the ileum with the pathological change to be almost solid when viewed grossly and, microscopically, showed tubulo‐papillary structures in addltlon to a cystic pattern. The DNA ploidy pattern revealed a near‐diploid aneuplold in the early specimen and a polyploid aneuploid in the last specimen.