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Clear cell odontogenic tumor in the mandible: Report of a case with an immunohistochemical study of epithelial cell markers
Author(s) -
Kumamoto Hiroyuki,
Kawamura Hiroshi,
Ooya Kiyoshi
Publication year - 1998
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1998.tb03959.x
Subject(s) - immunohistochemistry , pathology , odontogenic , mandible (arthropod mouthpart) , cell , medicine , odontogenic tumor , biology , anatomy , botany , genus , genetics
A ram case of clear cell dontogenic tumor Is presented with an immunohistochemical study using epithelial cell markem. A 35‐year‐old Japanese man was admitted with a complaint of painless swelling In the anterior region of his mandible. Radiological examination showed a relatively well‐defined multilocular radloiucency with root resorption of the adjacent teeth. Despite a subtotal mandlbulectomy, the tumor recurred thm times. Histologically, the tumor was composed of proiiferating clear cells and Infiltrated through the cancellous bone. Histochemical and ultrastruc‐tural analyses detected cytoplasmic glycogen granules in the clear cells. They showed immunoreaetivities for cytokeratin 8,13 and 19, fllaggrin and anti‐ameloblastoma antibodb, suggesting an odontogenic epithelial origin.