Premium
Ovarian mixed germ cell tumor composed of dysgerminoma, endodermal sinus tumor, choriocarcinoma and mature teratoma in a 44‐year‐old woman: Case report and literature review
Author(s) -
AKAHIRA JUNICHI,
LTO KIYOSHI,
KOSUGE SHYUICHI,
KONNO RYO,
SATE SHINJL,
YAJIRNA AKIRA,
SASANO HIRONOBU
Publication year - 1998
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1998.tb03935.x
Subject(s) - choriocarcinoma , dysgerminoma , germ cell tumors , immature teratoma , endodermal sinus tumor , placental alkaline phosphatase , germ cell , teratoma , pathology , human chorionic gonadotropin , ovarian tumor , medicine , chemotherapy , ovary , biology , cancer , ovarian cancer , alkaline phosphatase , gene , hormone , biochemistry , enzyme
A case of ovarian mixed germ cell tumor In a 44‐year‐old woman was examined. The tumor was well circumscribed, measured 15 times 11 times 10cm and appeared solid and partly cystic on the cut surface. Light microscopic examinations revealed that the tumor was composed of four different neoplastic germ cell elements, Intermingled with each other. They are: (i) choriocarcinoma, immunohistochemically positive for human placental lactogen (hPL) and human chorionic gonadotropin (hCG); (ii) dysgerminoma, positive for placental alkaline phosphatase; (iii) endodermal sinus tumor positive for α‐fetoproteln (AFP); and (lv) mature teratoma. Among these histological types, dysgermlnoma occupied more than 50% of the neoplasm. The patient was diagnosed as a stage la ovarian mixed germ cell tumor and was subsequently treated with chemotherapy. A second‐look laparotomy after completion of chemotherapy revealed no residual tumors in the abdomen and the patient Is alive and well 15 months after operation. This Is the fourth reported case of ovarian mixed germ cell tumor arising In patients over 40 years old.