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Macrofollicular variant of papillary thyroid carcinoma
Author(s) -
NAKAMURA TOSHITSUGU,
MORIYAMA SHINICHI,
NARIYA SHOJI,
SANO KENJI,
SHIROTA HIROSHI,
KATO RYOHEI
Publication year - 1998
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1998.tb03934.x
Subject(s) - pathology , papillary carcinoma , immunohistochemistry , left lobe , thyroid carcinoma , thyroid , medicine , lymph , carcinoma , vascular invasion , adenoma , cancer
A rare case of a macrofollicular variant of papillary thyroid carcinoma occurring in an 18‐years‐old male is described. The extirpated tumor, 5.5 × 5.5 × 3.5 cm In size, was well demarcated and multinodular, and histopathologically showed a predominantly macrofolllcular structure reminiscent of adenomatous goiter or macrofollicular adenoma. In the tumor tissue, however, there were several small foci of microfollicular or paplllary structure with the nuclei charae teristic of papillary carcinoma. Parts of the macrofollicular areas also showed similar nuclear characteristics with a transition to microfollicular or papillary areas. Incomplete capsular invasion and minimal vascular invasion were also present. Additional resected specimens contained small metastatic nodules in the residual left lobe and lymph nodes. Immunohistochemistry showed a small number of p53‐positive tumor cells in the microfollicular or papillary areas. It is suggested that this tumor is a well‐differentiated variant which should be distinguished from benign thyroid lesions, although there have been some cases of metastases which appear related to capsular and/or vascular invasion.