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Sebaceous carcinoma of the submandibular gland with high‐grade malignancy: Report of a case
Author(s) -
OHARA NOBUYA,
TAGUCHI KOHJI,
YAMAMOTO MAMI,
NAGANO TOSHIAKI,
AKAGI TADAATSU
Publication year - 1998
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1998.tb03907.x
Subject(s) - submandibular gland , pathology , sebaceous gland , pathological , malignancy , vimentin , carcinoma , sebaceous carcinoma , cytokeratin , medicine , immunohistochemistry
A case of sebaceous carcinoma arising in the left submandibular gland of a 66‐year‐old man is reported. The clinical and pathological examinations revealed a carcinoma, which was of salivary gland In origin, with regional lymph nodal metastases. Pathological findings showed features of highgrade sebaceous carcinoma with spindle myoepitheliomatous differentiation. Neither squamous cell nor duct epithelial‐like cell differentiation was noted. lmmunohistochsmically, tumor cells were positive for cytokeratin, S‐100 protein and vimentin. Lipid was demonstrated in the cytoplasm of the tumor cells. Ultrastructurally, tumor cells contained numerous intracyto‐plasmic lipid droplets. Myoepitheliomatous differentiation is rare in sebaceous carcinoma of the salivary gland. Presented is the second reported case of sebaceous carcinoma arising in the submandibular gland.