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Oligodendroglioma with signet‐ring ceil morphology: A case report with an immunohistochemical and ultrastructural study
Author(s) -
Mlkaml Yoshikl,
Shirabe Teruo,
Hate Sakae,
Watanabe Akira
Publication year - 1998
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1998.tb03884.x
Subject(s) - oligodendroglioma , pathology , cytoplasm , proto oncogene tyrosine protein kinase src , immunohistochemistry , morphology (biology) , ultrastructure , signet ring cell , biology , chemistry , medicine , microbiology and biotechnology , glioma , astrocytoma , cancer research , cancer , kinase , genetics , adenocarcinoma
A case of oligodendroglioma with signet‐ring cell (SRC) morphology arising in the right thalamic region in a 12‐year‐old boy Is described. Histopathologlcally, the tumor was a composite neoplasm consisting of typical oligodendroglioma and anaplastlc components with aggregates of SRC. Immunohlstochemlcally the SRC were negative for glial flbrlllary acidic protein (GFAP) but surrounded by GFAP‐posltlve anaplastlc cells with high‐grade nuclear features. Typical ollgodendrogllomatous components were negative for GFAP. The Ki‐67 labeling index evaluated with MIB‐1 antibody was 1.3% in the SRC component, 9.2% in the GFAP‐posltlve anaplastlc cell component, and 0.8% in the typical ollgodendrogllomatous component. Ultrastructurally, the cytoplasm of the SRC was filled with Irregularly and widely dilated clsternae of rough endoplasmic retlculum containing granular material. Intermediate filaments and a small number of other organelles were distributed in the pertnuctear and peripheral areas. Both the SRC and anaplastlc cells had slender cytoplasmic processes, although those of the SRC were short and few in number. These findings are distinct from those of SRC hitherto described in oligodendrogliomas to date, and suggest that there is a morphological heterogeneity in SRC rarely seen in oligodendrogliomas and that some examples of SRC are related to the anaplastic cells with astrocytic features in their origin.