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Nodular hidradenoma of the breast: Report of two cases with literature review
Author(s) -
Domoto Hideharu,
Terahata Shintaro,
Sato Kimiya,
Tamai Seiichi
Publication year - 1998
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1998.tb03860.x
Subject(s) - hidradenoma , pathology , medicine , breast cancer , nodule (geology) , differential diagnosis , quadrant (abdomen) , breast tissue , neoplasm , biology , cancer , paleontology
Two cases of nodular hidradenoma of the breast with possibly different origins are reported. Case 1 is of a 58 year‐old female wlth a breast mass in the left, outer lower‐quadrant. A histogenetical origin in the skin adnexal glands was suspected due to its superficial location and immuno‐histochemical findlngs. Case 2 is of a 44‐yearold male with a subareolar nodule and nipple discharge. Histological examlnation demonstrated that the tumor was located deep in the breast tissue, was surrounded by dilated mammary ducts and exhibited intraductal extenslons, which are all features mlmicking those of breast cancer. Immunohlsto‐chemical positivity against gross cystic disease fluid protein‐15 was weakly Identified and negativity for endo‐plasrnic reticulum was observed. This case can be interpreted as arising In the mammary ducts. It is well known that various kinds of skin adnexal tumors arise in the breast tissue; however, nodular hidradenoma of the breast is still a rare benign neoplasm. Cllnically, nodular hidradenoma of the breast tends to occur in the nipple or subareolar region of the female breast. It should be kept in mind that nodular hidradenoma may occur in mammary ducts and it should be included when differential diagnoses are made of subare olar breast tumors.