Premium
Systemic expression of a newly recognized protein, LECT2, in the human body
Author(s) -
Nagal Hisakazu,
Hamada Tomoml,
Uchida Toshikazu,
Yamagoe Satoshi,
Suzuki Kazuo
Publication year - 1998
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1998.tb03855.x
Subject(s) - pathology , expression (computer science) , biology , medicine , computer science , programming language
LECT2 (leukocyte cellderived chemotaxln 2) Is a new, recently isolated protein shown to be syntheslzed by hepstocytes. All hepntocytea show diffuse lmmunostalnlng for LECT2 within the cytoplasm. In the present study an attempt was made to Investigate the expression of LECT2 In normal and diseased human organs and tlssues, other than the Iiver, using indirect lmmunoperoxldase stalning. LECT2 was found to be generally expressed In vascular, endothellel and smooth muscle cells, adlpocytes, cerebral nerve cells, apical squamous epithelia, parathyrold cells, sweat and sebaceous glandular eplthella, Hassell bodies and some mononuclear cells In lmmunohematopoletlc tissue, although some of theae cells and tlssues were occaslonally unstained In dlseased condltlons. Attemathrely, thls protein was generally negatlve, although It was occasionally posltively stalned In osteoblasts, chondrocytes, cardlac and skeletal muscle cells, smooth muscle cells of the gastrolntestlnal tract, and the eplthellal cells of some tissues. LECT2 seems to be related to the cell cycle or repair process following damage to a variety of cells.