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Histological and biological characteristics of microinvasion in mammary carcinomas ≤ 2 cm in diameter
Author(s) -
Takasaki Takashi,
Akiba Suminori,
Sagara Yoshiatu,
Yoshida Hiroki
Publication year - 1998
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1998.tb03840.x
Subject(s) - basement membrane , pathology , immunohistochemistry , mammary gland , stroma , laminin , metastasis , lymph node , epithelium , carcinoma , biology , chemistry , medicine , extracellular matrix , cancer , breast cancer , microbiology and biotechnology , genetics
Fifty‐two mammary carcinomas, 2 cm or less in diameter, were examined in order to clarify the morphology and biology of microinvasion. The morphological characteristics of microinvasion of carcinomas include: (i) a loss of myoeplthelial cells and a rupture with concomitant loss of collagen IV and lamlnin in the basement membrane of involved mammary glands; and (ii) budding of carcinomas from the rupture into the stroma. When microinvasion was defined as a rupture of < 200 pm In the basement membrane with invasion, the number of microinvasions per 1 mm of basement membrane was larger in the tumors in which the area of invasion was larger. The prevalence of microinvasion showed a significant correlation with lymph node metastasis and the rate of histological deviation, while no correlation of expression of either estrogen receptors or progesterone receptors and c‐erbB‐2 protein was found. The study clarified that the early invasion of mammary carcinomas could be detected by the immunohistochemical method using anti‐smooth muscle actin, laminin and collagen IV antibodies. The study also suggested that microinvasion might be an indicator of lymph node metastasis in mammary carcinomas ≤ 2 cm diameter.