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Metastatizing low‐grade clear cell leiomyosarcoma of the uterus
Author(s) -
Karpuz Vildan,
Joris François,
Letovanec Nicolas,
Branchmanskl Franchise,
Kapanci Yusuf
Publication year - 1998
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1998.tb03833.x
Subject(s) - leiomyosarcoma , uterus , metastasis , neoplasm , smooth muscle , pathology , medicine , leiomyoma , smooth muscle tumor , hysterectomy , cell , biology , cancer , genetics
An unusual case of uterine clear cell tumor is reported In a 56‐year‐old woman. The neoplasm was Identified as a peculiar low‐grade leiomyosarcoma, composed mainly of watery, clear large cells with round, fairly regular nuclei. No appreciable pleomorphlsm or high mitotlc activity was noted. There was no necrosis. The presence of occasional areas of transition between these cells and typical spindle leiomyosarcoma cells, together with the immunohisto‐chemical results, allowed the recognition of a smooth muscle origin of this clear cell tumor. The patient was treated by hysterectomy. Six years later she developed an Inguinal metastasis resembling an hibernoma, and then later developed a large retroperitoneal metastasis, which was composed entirely of clear cells and was distinguished from a Ilposarcoma by Immunohlstochemlstry.