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Prognostic significance of Ki‐67, p53, and Bcl‐2 expression in prostate cancer patients with lymph node metastases: A retrospective immunohistochemical analysis
Author(s) -
Masuda Mitsunobu,
Takano Yasuo,
Iki Masayuki,
Asakura Tomoyuki,
Hashiba Takafumi,
Noguchi Sumio,
Hosaka Masahiko
Publication year - 1998
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1998.tb03826.x
Subject(s) - immunohistochemistry , medicine , lymph node , prostate cancer , univariate analysis , ki 67 , pathology , oncology , prostate , lymph , cancer , multivariate analysis
The prognostic significance of Ki‐67, p53, and Bcl‐2 expression was evaluated in prostate cancer patients with lymph node metastases. Immunohistochemical staining of archived material obtained from 56 patients was performed by the streptavldin‐biotin method. Univariate survival analysis showed that a Ki‐67 labeling index (Ki‐67 LI) of ≥8.4 in the primary tumor identified a group of patients with a significantly poorer prognosis (P<0.001). Furthermore, a Ki‐67 LI of ≥8.7 in the nodal metastatlc tumor was also associated with a poorer prognosis (P<0.01). Multivariate analysis showed that the Ki‐67 LI of primary tumors (P<0.01) and lymph node metastases (P<0.01) had independent prognostic value. p53 and Bcl‐2 expression had no prognostic value in patients with prostate cancer and lymph node involvement. The Ki‐67 LI has more prognostic value than p53 and Bcl‐2 expression for patients with prostate cancer that has spread to the lymph nodes.