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Mucinous adenocarcinoma arising in a giant urachal cyst associated with pseudomyxoma peritonei and stromal osseous metaplasia
Author(s) -
Sasano Himnobu,
Shlzawa Soichirou,
Nagura Hiroshi,
Yamaki Toshihiko
Publication year - 1997
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1997.tb04531.x
Subject(s) - pseudomyxoma peritonei , pathology , medicine , cyst , metaplasia , abdominal cavity , adenocarcinoma , carcinoembryonic antigen , calcification , cystadenoma , anatomy , appendix , biology , pancreas , cancer , paleontology
An unusual urachal lesion, which Is a muclnous adenocarcinoma arising in a giant urachal cyst and is associated with pseudomyxoma peritonei and stromal osseous metaplasia of the cyst wall, was examlned in a 45‐year‐old male. m cyst was encapsulated, measured 22×20 ×20 cm and weighed 3800 g. The unilocular cavlty was filled with much. Most of the cystic cavity was lined with tall, slmple or stratifled columnar eplthellum wlth a focus of papillary provon into the cavity. These findings suggest that this cystic lesion represents cystadenoma rather than a simple cyst. Foci of lnvasive moderately differentiated mucinous adenocarclnoma were detected in the area of macroscopic papillary fronds. Carcinoembryonic antigen and CA19–9 were immunohistochemically positive for tumor cells and their serum levels were also elevated. Stromal dystrophic calcification was extensively observed In the cyst wall with focl of osseous metaplasia. Muclnous Implants, whlch histologically demonstrated adherent muclnous masses without epithellal components on the surface, were observed in the pelvic and abdominal cavity, lndicating pseudomyxoma peritonei.