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Adrenal rest tumor of the broad ligament: Case report with immunohistochemical study of steroidogenic enzymes
Author(s) -
Sasano Hironobu,
Sato Shinji,
Yajima Akira,
Akarna Jirou,
Nagura Hiroshi
Publication year - 1997
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1997.tb04529.x
Subject(s) - pathology , lesion , immunohistochemistry , rest (music) , broad ligament , adrenal cortex , biology , chemistry , endocrinology , uterus , medicine
An adrenal rest tumor of the broad ligament was studled In a 43‐year‐old woman. The tumor measuring 6×3×3 cm and appearing as golden‐yellow on the cut surface was lncidentally discovered during a total hysterectomy due to uterine leiomyoma. The encapsulated tumor was predominantly composed of pale and lipid‐rich cells arranged in alveolar clusters or short blunt cords. Electron microscopic examination revealed mitochondria with tubule‐veslcular cristae and abundant lipid droplets. Adrenal 4‐binding proteln, a transcriptional factor of steroidogenesis, was present in almost all of the tumor cells, suggestive of steroldogenic features in the lesion. lmmunoreactivity of steroidogenic enzymes involved In adrenocortical steroid production was detected in the tumor cells, suggesting that tumor cells had the potential to synthesize adrenocortical steroids. A relativety low KI‐67 labeling index (3.20±1.15 per 100 tumor cells) and an absence of necrosis and vascular andlor capsular invasion suggest benlgnity of the leslon.