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Epstein‐Barr virus (EBV) ‐induced CD30 + natural killer cell‐type malignancy resembling malignant histiocytosis: Malignant transformation in chronic active EBV infection associating hypogammaglobulinemia
Author(s) -
Tsutsumi Yutaka,
Tang Xiaoyan,
Yamada Takuji
Publication year - 1997
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1997.tb04512.x
Subject(s) - biology , pathology , malignant histiocytosis , natural killer cell , immunology , epstein–barr virus , hepatosplenomegaly , virus , medicine , cytotoxic t cell , histiocyte , biochemistry , disease , in vitro
A 27‐year‐old male suffered from Epstein‐Barr virus (EBV)‐related liver dysfunction with persistent hypogammaglobulinemia. IgG titers to EBV antigens were significantly high, while other hepatitis markers were negative. Liver biopsy disclosed active intralobular inflammation. Two years later, he manifested persistent fever, leukopenia, effusions and hypopmteinemia. and his general condition worsened progressively. the peripheral blood small lymphocytes predominantly expressed natural killer (NK)‐like phenotypes (CDP, CD7+, CD16+, CD56+). Hepatosplenomegaly and marked elevation of serum lactic dehydrogenase were observed. He died of respiratory failure at the age of 29. At autopsy, the liver (2190 g), spleen (860 g), small bowel and mesenteric lymph nodes showed massive Infiltration of large atypical lymphoid cells in close association with hemophagocytic histiocytes. Involvement was mildly noted also in the bone marrow, lungs, gall‐bladder and kidneys. The atypical cells belonged to CD30+ activated NK‐type cells expressing CD2, cytoplasmic CD3, CD7, CD45RO, CD56, HLA‐DR and HLA‐DQ.T cell receptors (TCR), surface CD3, CD4, CD5 and CD8 were not expressed. Epstein‐Barr virus‐related small nuclear RNA (EBER1) and Epstein‐Barr virus‐associated nuclear antigen 1 were detected In the nuciel of a significant number of atypical cells, while EBV‐related latent membrane protein‐1 was negative. EBER1 was also Identified In the nuclei of non‐neoplastic small lymphocytes at both biopsy and autopsy. Monoclonal integration of the EBV genome into the lymphoma cells was shown by Southern blot analysis. Clonal rearrangement of TCR was undetectable. Roles of chronic active EBV infection in the development of NK cell‐type malignancy resembling malignant histiocytosis are discussed.