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Sarcomatoid hepatocellular carcinoma with osteoclast‐like giant celIs: Case report and immunohistochemical obsewations
Author(s) -
Sasakl Atsushi,
Yokoyama Shigeo,
Nakayama Iwao,
Nakashlma Kimihiro,
Kim Yangll,
Kitano Seigo
Publication year - 1997
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1997.tb04500.x
Subject(s) - hepatocellular carcinoma , pathology , immunohistochemistry , mesenchymal stem cell , histiocyte , giant cell , osteoclast , medicine , cancer research , receptor
Hepatocellular carclnoma (HCC) with osteoclast‐like giant cells (OGC) developed in the cirthotic liver of a 42‐year‐old male. Serum protein induced by vitamin K absence or antagonist II was elevated preoperatively. The patient died of the disease on the 28th postoperative day. Hlstologically, the tumor consisted of OGC and mononuclear cells (MC). The OGC were characterized by benign‐appearing nuclei, whereas the MC had atyplcal nuclei with a considerable number of mitoaes. A vaguely trabecular pattern was observed In the focal area of the tumor, but no evidence of overt HCC was found. lmmunohlstochemical analysis revealed that both OGC and MC were diffusely positive for histlocytic and mesenchymal markers. Some MC were focally posltive for cytokeratins 7, 8 and 19, and for albumin. Our clinical, histological and Immunohistochemical findings suggest that the MC were derived from hepatocytes, with some mesenchymal features, but the OGC were non‐neoplastic and reactive histiocytes.