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Gastrointestinal autonomic nerve tumors: Immunohistochemical and ultrastructural studies in cases of gastrointestinal stromal tumor
Author(s) -
Matsumoto Koshi,
Min Wen,
Yamada Nobutaka,
Asano Goro
Publication year - 1997
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1997.tb04498.x
Subject(s) - pathology , immunohistochemistry , ultrastructure , gist , stromal cell , myenteric plexus , stromal tumor , schwann cell , nerve plexus , nerve sheath tumor , s100 protein , submucous plexus , schwannoma , biology , anatomy , medicine
The gastrolntestlnal autonomic nerve tumor (GAN tumor) is an uncommon stromal tumor with a morphological feature resembling the cell processes of the enteric plexus, and was originally teimed a plexoma or plexosarcoma. Light microscoplc studies show the GAN tumor most often consists of spindle‐shaped cells indistinguishable from a smooth muscle tumor or Schwann cell tumor. Immunohistochemical and ultrastructural examinations of 18 cases of gastrointestinal stromal tumor (GIST) were performed. During ultrastructural examination, all of the 12 cases which were immunohisto‐chemically positive for S‐100 protein or neuron‐specific eno‐lase (NSE) showed synapse‐like structures containing dense core neurosecretory granules measuring 100–200 nm, and 40–60 nm endocytoplasmic vesicles. These results suggest that most GIST of neurogenlc origln are tumors derived from the myenteric nerve plexus.