Premium
Glomerular sequence of events concerning monocyte/ macrophage accumulation and ICAM‐1 expression during experimental serum sickness nephritis in the rat 2
Author(s) -
Yang Xiuying
Publication year - 1997
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1997.tb04486.x
Subject(s) - mesangium , nephritis , glomerulosclerosis , icam 1 , glomerulonephritis , cell adhesion molecule , glomerular mesangium , pathology , intercellular adhesion molecule 1 , monocyte , chemistry , biology , immunology , medicine , proteinuria , endocrinology , kidney
Serum sickness nephritis was induced in Fisher rats by preimmunization and repeated immunization with chicken egg albumin. This experimental model is characterized by marked accumulation of monocytes/macrophages (MO) and deposition of immune complexes (IC) in glomerull during the inflammatory stage and, thereafter, the advancement to glomeruloscierods. The correlations between glomerular tissue damage, MO participation, intercellular adhesion molecule‐1 (ICAY‐1) expression and IC deposition were analyzed during the long‐term disease process. The grade of ICAM‐1 expression was well correlated with MO accumulation and IC deposition, and its distribution was observed on the glomerular endothelial layer, mesanglum, and along the parietal epithelial layer of the Bowman's capsule. It is suggested that glomerular MO accumulation is largely affected by the ICAM‐1 expression on glomeruli and, underneath such adhesion molecules, MO may play a role In subendoth‐elial or mesangial migration, mesangial cell activation, inducing sclerosis and monocytic‐epithellal crescent formation.