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Numerous eosinophilic globules (skeinoid fibers) in a duodenal stromal tumor: An exceptional case showing smooth muscle differentiation
Author(s) -
Matsukuma Susumu,
Doi Masateru,
Suzuki Masatoshi,
Ikegawa Kazuya,
Sato Kimiya,
Kuwabara Noriyuki
Publication year - 1997
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1997.tb04459.x
Subject(s) - pathology , stromal cell , immunohistochemistry , eosinophilic , ultrastructure , stromal tumor , biology , actin , anatomy , chemistry , microbiology and biotechnology , medicine
A unique case of duodenal stromal tumor In a 51‐year‐old man is reported. The tumor histologically showed spindle cell proliferation and numerous eosinophilic globules. Most globules were composed of tangled 45 nm thick fibrils, which were ultrastructurally Identical to ‘skelnoid fibers’. The presence of glycogen granules in the tumor cells and the Immunoreactivity for α‐smooth muscle actin suggested smooth muscle differentiation. Focal ultrastructural findings also supported the smooth muscle nature of this tumor. There were no immunohistochemical and ultra‐structural features indicating neural differentiation. In previous studies, the presence of such ‘skeinoid fibers’ was suggested to be a histological marker for neural differentiation in gastrointestinal stromal tumor. However, the findings In the present case suggest that numerous ‘skeinoid fibers’ can be Identified in duodenal stromal tumor with smooth muscle differentiation, although this condition may be rare.