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Bile canaliculi‐like lumina in fibrolamellar carcinoma of the liver: A light‐ and electron‐microscopic study and three‐dimensional examination of serial sections
Author(s) -
Sato Shinichiro,
Masuda Tomoyuki,
Oikawa Hiroki,
Satodate Ryoichi,
Suzuki Kazuyuki,
Sato Shunichi,
Suzuki Akihiko,
Monma Nobuhiro
Publication year - 1997
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1997.tb04454.x
Subject(s) - bone canaliculus , pathology , intracellular , electron microscope , chemistry , anatomy , carcinoma , biology , medicine , optics , physics , biochemistry
Flbrolamellar carclnoma (FLC) Is a varlant of hepatocellular carcinoma characterlzed by dlstlnct pathologicel features. The presence of Intracellular lumlna resembling blle canalicull was previously reported in tumor cells of FLC on electron microscopy. Using light microscopy, we describe the presence of intracellular lumina In FLC, which was resected from a 15‐year‐old Japanese girl, as round structures lined with a brush‐like border. These lumina occasionally contained blle. Light microscopic examination of 1 μm thick serial sections of Eponembedded tissue samples showed that the lumina were located in the intracellular space without any connection to the Intercellular space. However, we also detected a small number of lumlna that were lined by microville which were present between adjacent tumor cells. Results suggest that the presence of the Intracellular Iumlna in tumor cells probably represents a common histopathologic feature of FLC.