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Cystic pulmonary metastases of endometrial stromal sarcoma of the uterus, mimicking lymphangiomyomatosis: A case report with immunohistochemistry of HMB45
Author(s) -
Itoh Tomoo,
Mochizuki Makoto,
Kumazaki Satoshi,
Ishihara Teruo,
Fukayama Masashi
Publication year - 1997
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1997.tb04449.x
Subject(s) - pathology , desmin , immunohistochemistry , lymphangioleiomyomatosis , medicine , endometrial stromal sarcoma , differential diagnosis , lung , sarcoma , hamartoma , tuberous sclerosis , vimentin
A case of endometrial stromal sarcoma (ESS) showed cystic pulmonary metastases mimicking lymphangiomyomatosis (LAM). A 58‐year‐old female, who had undergone total hysterectomy for low‐grade ESS 16 years previously, had repeated bouts of pneumothorax. Multiple then‐walled cysts in the perlpheral lung were revealed by radiological examinations. In an open‐lung blopsy specimen, cystlc lesions were surrounded by layers of spindle‐shaped cells of varying thickness that resembled LAM. However, In addltion to subtle histological differences from LAM, HMB45 (antimelanoma antibody) showed positive In LAM (n=3), but was negative in ESS (M) and the cystlc leslons of this case. Using myogenic markers (desmin and α‐smooth muscle actin), metastatlc ESS could be immunohistochemically differentiated from mesenchymal cystlc hamartoma (n=1). HMB45 Immunohistochemistry is useful in the differential diagnosis of cystic puimonary lesions.