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Pulmonary hemorrhage and antiglomerular basement membrane antibody‐mediated glomerulonephritis after exposure to smoked cocaine (crack): A case report and review of the literature
Author(s) -
M Ginesa,
Bragado Federico García,
M Ana
Publication year - 1997
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1997.tb04443.x
Subject(s) - goodpasture's syndrome , goodpasture syndrome , basement membrane , medicine , immunofluorescence , pulmonary hemorrhage , pathology , rapidly progressive glomerulonephritis , anuria , direct fluorescent antibody , renal biopsy , glomerulonephritis , glomerular basement membrane , antibody , lung , immunology , biopsy , kidney
A case of Goodpasture's syndrome with a negative immunofluorescence examination of the lung biopsy in a 32‐year‐old man is described. The patient was a 40 clgarettes per day smoker, who had been smoking cocaine (crack) up to 3 weeks before hospital admission. He developed a diffuse alveolar hemorrhage with extremely acute respiratory distress, followed by renal failure with anuria. Transluguiar renal blopsy, Immunofluorescence and serum antiglomerular basement membrane antibody titer studies conflrmed the diagnosls of Goodpasture's syndrome without linear Jmmunogiobulln G deposlts as determined by Immunofluorescence examination of the alveolar basement membranes. The case Illustrates the potentially complex Interrelations between an autoimmune disease and exposure to substances with possible antigenic properties, besides the Imperative necessity for an early, accurate diagnosis and treatment for the potential for threatening life. Moreover, the association of Goodpasture's syndrome with crack has not been previously reported.