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Giant cell tumor of bone: Frequent actin immunoreactivity in stromal tumor cells
Author(s) -
Watanabe Kazuo,
Tajino Takahiro,
Kusakabe Takashi,
Saitoh Atsuko,
Suzuki Toshimitsu
Publication year - 1997
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1997.tb04441.x
Subject(s) - stromal cell , pathology , cd68 , giant cell tumor of bone , giant cell , actin , cytoplasm , immunohistochemistry , peripheral blood mononuclear cell , biology , medicine , microbiology and biotechnology , in vitro , biochemistry
Although giant cell tumor (GCT) of bone is a well‐recognized neoplasm with distinctive clinical and histopathological features, the origin of tumor cells, particularly of mononuclear cells, has not yet been established. An immunohistochemicai study was carried out on 11 cases of GCT of bone to examine the cellular natures of stromal mononuclear cells. In all cases, stromal cells were positive for muscle actin (HHF35) or α‐smooth muscle actin, and in eight of 11 cases, positivist was intense and extensive. The cell margin of osteoclast‐like giant cells (OGC) was stained positively by muscle actin, In addition to Intense and diffuse positive staining of the cytoplasm for KP1 (CD68), whereas α‐smooth muscle acting exhibited a negative reaction on the OGC. In conclusion, the tumor cells with muscle actin and α‐smooth muscle actin proclivities are not rare but frequently numerous In the GCT of bone; whereas further observation Is necessary to elucidate whether the stromal cells exhibit myoflbroblastlc cell differentiation exactly.