Premium
Calcifying fibrous pseudotumor
Author(s) -
Fukunaga Masaharu,
Kikuchi Yasushi,
Endo Yasuhiko,
Ushigome Shinichiro
Publication year - 1997
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1997.tb04435.x
Subject(s) - desmin , vimentin , pathology , cytokeratin , cd34 , cd31 , actin , intermediate filament , myoepithelial cell , anatomy , neurofilament , biology , chemistry , immunohistochemistry , medicine , cytoskeleton , microbiology and biotechnology , genetics , stem cell , cell
A case of calcifying fibrous pseudotumor arising In the lngune of a 20‐year‐old Japanese female Is described. The patient had a well‐circumscrlbed subcutaneous mass measuring 2.0 cm In greatest diameter, which had been present for 3 months. Mlcroscoplcally. the tumor was not encapsulated but well defined. The tumor was composed largely of dense interwoven bundles of collagen. Uniform, elongated spindle cells were scattered among the collagenous bundles and showed a wavy pattern. Lymphoid follicles with germinal centers and an infiltration of lymphocytes and plasma cells wore intermingled. The tumor was characterized by the presonce of micracalcifications, chiefly dystrophic calcifications, throughout the Iesion. The spindle cells were diffusely positive for vimentin and α‐smooth muscle actin. They were uniformly nagative for desmin, muscle specific actin HHF35, frctor‐VII related antigen, S‐100 protein. neurofilament, cytokeratin CAM5.2, CD34, and CD31. By flow cytometry the tumor had a diplold DNA content with S‐phase fractions of 2.5%. The patient was well with no evidence of disease 2 months after excision.