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Regular immunohistochemical localization of endothelin‐1 and endothelin‐B receptor in normal, hyperplastic and neoplastic human adrenocortical cells
Author(s) -
Hiraki Hiroyukl,
Hoshi Nobuo,
Hasegawa Hiroshl,
Tanigawa Toshitaka,
Emura Lwao,
Seito Tsutomu,
Yamakl Toshifumi,
Fukuda Takeakl,
Watanabe Kazuo,
Suzuki Toshimitsu
Publication year - 1997
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1997.tb03730.x
Subject(s) - receptor , hyperplasia , adenoma , endocrinology , endothelin receptor , adrenocortical carcinoma , pathology , adrenal cortex , zona glomerulosa , adrenocortical adenoma , endothelin 1 , medicine , biology , angiotensin ii
The locallzation of endothelin (ET)‐l/blg ET‐1, ET‐3/big ET‐3, ET‐A and ET‐B receptor was Immunohistochemlcally examined in human adrenal glands composed of 36 normal cases, nine hyperplasla, 70 adenomas and seven carcinomas of cortical cells. In normal adrenals, ET‐1/blg ET‐1 and ET‐B receptor were regularly detected In the cortical cells, especially in the zona fasciculata for ET‐1 and zone glomerulosa for ET‐B receptor but not in the medulla, while ET‐A receptor localized occasionally in endothelial cells or rarely in cortical cells and ET‐3/blg ET‐3 was very limited In the cortical cells. In hyperplasia, adenoma and carcinoma, ET‐1 /big ET‐1 and ET‐B receptor showed frequent localization, although focal distrlbutlon of the ET‐B receptor was rather predominant in these groups. ET‐A receptor and ET‐3/big ET‐3 were very Infrequently expressed. Functioning versus non‐functioning and hypertensive versus normotenshe cases revealed no significant differences in the frequency of posltive cells for ET‐l /big ET‐1, ET‐3/big ET‐3, ET‐A receptor or ET‐B receptor. Alternatively, the frequency of lmmunoreactivtty to ET‐1/big ET‐1 or ET‐B receptor significantly decreased in hyperplasia, adenoma and carcinoma, when compared wlth that of normal adrenal cortex. The present study, therefore, indicates that ET‐1 /big ET‐1 and ET‐B receptor are a prevalent Iigand‐receptor system In normal and hyperplastic/neoplastic adrenocortical cells, even wkh a malignant prdle, and may contribute in maintalnlng adrenocortical cell function or cell viability but not cell growth or systemic hypertension.