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Aortic intimal sarcoma with acute myocardial infarction
Author(s) -
Nanjo Hiroshi,
Murakami Masayo,
Ebina Toshihito,
Hoshi Naoto,
Sasaki Toshiki,
Zhuang Yong Jie,
Kobayashi Mikio,
Kawamura Koichi,
Masuda Hirotake
Publication year - 1996
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1996.tb03671.x
Subject(s) - medicine , autopsy , aorta , myocardial infarction , aortic arch , ascending aorta , thrombus , sarcoma , coronary arteries , thoracic aorta , pathology , lumen (anatomy) , cardiology , artery
An autopsy case of aortic sarcoma who died of acute myocardial infarction caused by coronary involvement is reported. The patient was a 54 year old woman who was admitted because of an undiagnosed fever and general fatigue of 6 months duration. Magnetic resonance imaging (MRI) showed a tumor in the aortic arch. Total aortic arch replacement was performed, it was diagnosed as a malignant mesenchymal tumor of the aorta. The patient died of acute myocardial infarction 10 months after the operation. At autopsy, the tumor had invaded the luminal surface and intima of the proximal anastomosis (the remnant ascending aorta and the graft), the aortic valves, the distal anastomosis (surgical line of the thoracic aorta plus the graft), and the coronary arteries. The left main coronary artery showed complete obstruction by fibrin thrombus with tumor invasion in the intima, which was responsible for acute myocardial infarction. Primitive and bizarre tumor cells proliferated with many slit‐like tissue spaces. Most of the tumor except for its luminal surface showed necrosis. Ultrastructurally, there were spaces between tumor cells, suggesting lumen formation, and some of them had microvilli. This sarcoma was considered to be the so‐called aortic intimal sarcoma.