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Metanephric adenoma of the kidney: Ultrastructural, immunohistochemical and lectin histochemical studies
Author(s) -
Ban Shinichi,
Yoshli Shinichi,
Tsuruta Atsushi,
Gotoh Yoshiya,
Onda Tomoko,
Shimlzu Yoshlhiko,
Shibata Toshikatsu
Publication year - 1996
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1996.tb03669.x
Subject(s) - pathology , vimentin , basal lamina , cytokeratin , immunohistochemistry , cuboidal cell , peanut agglutinin , soybean agglutinin , agglutinin , lectin , wheat germ agglutinin , ultrastructure , biology , anatomy , chemistry , medicine , microbiology and biotechnology
A case of metanephric adenoma, a rare benign tumor of the kidney is reported, and the results of ultrastructural, immunohistochemical, and lectin histochemical studies are presented. The patient was a 47 year old Japanese man presenting wlth a left renal tumor by ultrasonography. The nephrectomy material revealed a well‐demarcated tumor with medullary appearance, and on histological examination the tumor was composed of cuboidal cells forming regular small tubules with hyallnous stroma. Incomplete glomeruloid structures were formed in a few elongated tubules com‐posed of columnar cells. Metanephric blastema was not observed in the tumor or in the normal kidney. By electron microscope, the tumor cells were observed to be immature cells with microvilli at the apical surfaces. The neoplastic tubules were surrounded by basal lamina. The tumor cells were immunoreactive for Leu 7, epithelial membrane antigen, vimentin, and low molecular weight cytokeratin, and were weakly immunoreactive for S‐100 protein. Peanut agglutinin, soybean agglutinin, and Dollchos bifiorus agglu‐tinin were bound to the apical surfaces of the tumor cells.