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Uterine leiomyosarcoma with osteoclast‐like giant cells: Histopathological and cytological observations
Author(s) -
Watanabe Kazuo,
Hiraki Hiroyuki,
Ohishi Mari,
Mashiko Kazuyuki,
Saginoya Hideo,
Suzuki Toshimitsu
Publication year - 1996
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1996.tb03668.x
Subject(s) - cd68 , giant cell , pathology , leiomyosarcoma , histiocyte , osteoclast , histology , uterus , immunohistochemistry , smooth muscle tumor , anatomy , smooth muscle , staining , biology , medicine , receptor
A 56 year old woman presented with abnormal uterine bleeding. Except for a myomatous uterus, no other abnormalities were noted on physical examination and in radiographic and serologic studies. The hysterectomy specimen revealed an 8 cm uterine fundic tumor composed of two histologically different patterns that merged with one another; one was a well differentiated leiomyosarcoma and the other a mixture of osteoclast‐like giant cells (OGC) and plump spindle cells whose cell borders blended, resembling the histology of giant cell tumor of bone. lmmunohistochemical studies showed positive staining for muscle actin, α‐smooth muscle actin, and KP‐1 (CD68) in both the spindle cells and OGC. The latter also stained for α‐1‐antitrypsin and α‐1‐antichy‐motrypsln. These findings suggested that OGC may be formed by the fusion of spindle cells of leiomyosarcoma and also express histiocytic markers.