Premium
Salivary duct carcinoma: A clinicopathologic study of three cases with a review of the literature
Author(s) -
Minamiguchi Sachiko,
Iwasa Yoko,
Shoji Kazuhiko,
Higuchi Kayoko,
Watanabe Chihiro,
Haga Hironori,
Nakashima Yasuaki,
Yamabe Hirohiko
Publication year - 1996
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1996.tb03663.x
Subject(s) - myoepithelial cell , pathology , salivary duct carcinoma , medicine , cribriform , metastasis , carcinoma , salivary gland , adenocarcinoma , cancer , immunohistochemistry
Three cases of salivary duct carcinoma are presented. They occurred in a 60 year old man, a 66 year old man and a 57 year old woman. All of the lesions were located In the parotid gland. The tumor size ranged from 3 to 5 cm across the largest diameter. Facial paralysis was observed in two cases. Histologically, intreductal and invasive adenocarcinoma showing papillary, cribriform, and solid patterns with comede like necrosis was observed. lmmunohistochemically, the tumor cells were positive for keratin and epithelial membrane antigen. No myoepithelial cells were demonstrated within the tumor by staining for S‐100 protein, α‐smooth muscle actin or muscle specific actin. Ultrastncturally, intracytoplasmic lumina with microvilli, a moderate number of mltochrondria, lysosomes, and tight junctions were found. Regional lymph node metastasis was observed in one case, and distant metastasis developed in two cases. All of me patients were treated with adjuvant postoperative irradiation. One patient died of disease at 11 months after the initial diagnosis, another was alive with disease at 8 months, and the third patient was alive without disease at 2 years and 3 months. Salivary duct carcinoma should be ditterentiated from low‐grade salivary gland carcinomas using morphologic and clinical criteria because of its poor prognosis even with aggressive therapy.