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Epstein‐Barr virus‐associated post‐transplant primary smooth muscle tumor of the liver: Report of an autopsy case
Author(s) -
Sadahira Yoshito,
Moriya Takuya,
Shirabe Teruo,
Matsuno Tsuyoshi,
Manabe Toshiaki
Publication year - 1996
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1996.tb03660.x
Subject(s) - pathology , virus , autopsy , smooth muscle tumor , liver transplantation , epstein–barr virus , transplantation , in situ hybridization , lesion , biology , epstein–barr virus infection , kidney , medicine , virology , immunohistochemistry , endocrinology , messenger rna , gene , biochemistry
Epstein‐Barr (EB) virus‐associated primary smooth muscle tumors have been reported in immunosuppressed young patients with acquired immunodeficiency syndrome (AIDS) and young people who have undergone liver transplantation. An autopsy case of EB virus‐associated smooth muscle cell tumor in a 21 year old female who received immunosuppres‐sive therapy following renal transplantation Is repotted. Multiple tumor nodules were present in the liver, but no primary lesion was found in any other organ. Histologically, the nodules were composed of spindle cells, positive for α‐smooth muscle action, which were arranged in fascicles and closely associated with vascular channels, thereby suggesting a vascular smooth muscle cell origin. EB virus infection of the tumor cells was clearly demonstrated by in situ hybridization with an EB virus‐encoded RNA 1 (EBER‐1) probe. The present case illustrates that EB virus infection may play some role in the development of smooth muscle tumors not only in immunocompromised young patients with liver allo‐grafts, but also in those with renal allografts.