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Small‐cell neuroendocrine carcinoma of the uterine cervix associated with micro‐invasive squamous cell carcinoma and adenocarcinoma in situ
Author(s) -
Toki Toshihiko,
Katayama Yosei,
Motoyama Teiichi
Publication year - 1996
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1996.tb03648.x
Subject(s) - pathology , adenocarcinoma , neuroendocrine differentiation , cervix , carcinoma , carcinoma in situ , cell , biology , small cell carcinoma , population , medicine , cancer , environmental health , prostate cancer , genetics
A case of small‐cell neuroendocrine carcinoma of the uterine cervix associated with squamous cell carcinoma and adenocarcinoma In situ is reported. The tumor consisted mainly of uniform small cells with a population of intermediate cells that resembled carclnold tumor cells. Foci of micro‐invasive squamous cell carcinoma and adenocarcinoma In situ were recognized separately, adjacent to the main tumor. Both Gri‐mellus stain and Immunostalning of serotonin were positive for small‐cell and Intermediate‐cell carcinoma. Neurosecre‐tory granules were demonstrated by electron microscopy. Mlcroaclnl with positive mucln staining and microvilli‐like structures suggested glandular or exocrine differentiation of trie tumor. Three distinctive types of differentiation, neuroendocrine, exocrine and squamous characteristics, were expressed In the tumor.