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Late bone metastasis from an encapsulated follicular carcinoma of the thyroid withoutcapsular and vascular invasion
Author(s) -
Mizukami Yuji,
omura Akltaka,
Hayashi Yoshinobu,
Ohmura Kenji,
Michigishi Takatoshi,
Nogucrtl Masakunl,
Nakamura Shinobu,
Ishizaki Takeshi
Publication year - 1996
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1996.tb03637.x
Subject(s) - thyroid , pathology , follicular phase , medicine , metastasis , vascular invasion , thyroid carcinoma , atypia , follicular carcinoma , thyroidectomy , adenoma , nuclear atypia , immunohistochemistry , papillary carcinoma , cancer
A unique case of encapsulated follicular carcinoma of the thyroid, which lacked histologic evidence of capsular and vascular Invasion but developed a late bone metastasis, is described. The thyroid tumor was found in a 42‐year‐old man. It was relatively small (2.5 cm) and totally encapsulated. Histologically, the thyroid tumor showed a microfollicular growth pattern of follicular cells and revealed no histologic evidence of nuclear atypia, mitotic figures or capsular and vascular invasion. The diagnosis of microfollicular adenoma was made and partial thyroidectomy was performed. Bone (rib) metastasis of the thyroid tumor developed 22 years after the thyroidectomy. The present case suggested that capsular and/or vascular invasion is not always sufficient for the diagnosis of encapsulated follicular carcinoma of the thyroid.