Premium
Do epidermal Langerhans cells, migrating from skin lesions, induce the paracortical hyperplasia of dermatopathic lymphadenopathy?
Author(s) -
Shamoto Mtkihiro,
Osada Akiko,
Shlnzato Masanorl,
Kaneko Chiyuki,
Yoshida Asako
Publication year - 1996
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1996.tb03620.x
Subject(s) - pathology , lymph , antigen , hyperplasia , chemistry , follicular dendritic cells , cd1 , antibody , biology , medicine , antigen presenting cell , immunology , t cell , immune system , interleukin 21 , cd8
In the present study, immunohlstochemical and Immuno‐electron microscopic techniques were used to differentiate Langerhans cells (LC) from interdigitating cells (IDC) in the lymph nodes (LN) of dermatopathic lymphadenopathy. The majority of the dendritic cells that existed In the LN of dermatopathic lymphadenopathy were positive for OKT‐6 (CD la) antibody. It was concluded that these dendritic cells were not IDC, but LC. Electron microscopically, LC In these LN contained a few Blrbeck granules (BG). In order to prove the fact that these dendritic cells were LC, the existence of BG was investigated ultrastructurally by examining serial sections, and Immunoelectron microscopically for CD 1a positive cells. Most of the LC in the lymph nodes we examined were negative for the anti‐prollferating nuclear antigen (PCNA) antibody. This finding may mean that LC in the LN are fully developed cells and do not divide In the LN. Langer‐hana cells may migrate from the skin lesions to the paracortical areas in the LN, which then may become enlarged.