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Glomerulonephritis with predominant paramesangial IgG deposition
Author(s) -
Kano KenichI,
Ueda Yoshlhiko,
Iidaka Kazunari,
Ichimura Tohju
Publication year - 1996
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1996.tb03616.x
Subject(s) - proteinuria , pathology , renal biopsy , biopsy , mesangial proliferative glomerulonephritis , medicine , antibody , glomerulonephritis , microscopic hematuria , immunology , kidney
The new clinicopathological entity, Immunoglobin G (IgG)‐associated mesangial prollferative glomerulonephritls (GN), has been reported recently, but serial renal biopsies were not performed In the cases reported. The findings of three serial renal biopsies In a pediatrlc case with IgG‐associated GN and paramesangial deposits are reported. Microscopic hematuria was found Incidentally at the age of 8 years and the hematuria often worsened transiently during periods of upper respiratory infections. The patient was treated mainly with dipyrldamole. The third biopsy showed that both para‐mesangial hemispherical deposits and predominant mesan‐gial IgG deposits had increased, while mesangial cell proliferation had markedly decreased. These serial biopsy findings suggest that IgG‐associated GN with microscopic hematuria and slight proteinuria may be characterized by a relatively benign histoiogical and clinical course, as described in recent reports.