Premium
Granular cell tumor expressing myogenic markers in the prostate
Author(s) -
Furthata Mutsuo,
Sonobe Hiroshi,
Iwata Jun,
Ido Eiji,
Ohtsukl Yuji,
Kuwahara Morimasa,
Fujisaki Nobuta
Publication year - 1996
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1996.tb03614.x
Subject(s) - pathology , prostate , medicine , cell , biology , cancer , genetics
A granular cell tumor in the prostate of a 72 year old male is reported. The tumor nest was composed of large polygonal tumor cells, possessing cytoplasmlc eoslnophlllc granules which were positive with PAS stain and resistant to diastase digestion. Immunohistochemically, most tumor cells were strongly positive with anti‐α‐smooth muscle actin and ‐neuron specific enolase antibodies. Only a few scattered tumor cells were reacted with antt‐S‐100 protein antibody. These find‐Ings might suggest smooth muscle differentiation of this case, and provide an additional Insight into the histogenesis of granular cell tumors, especially In their heterogeneity.