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Different expression of Bcl‐2 protein in gastric adenomas and carcinomas
Author(s) -
Uesugi Hidenaga,
Saegusa Makoto
Publication year - 1996
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1996.tb03610.x
Subject(s) - grading (engineering) , adenoma , atypia , pathology , malignancy , carcinogenesis , carcinoma , ki 67 , biology , immunohistochemistry , cancer research , medicine , cancer , ecology
In order to cast light on the possible role of bcl‐2 protein (Bcl‐2) expression In gastric tumorigenesis, 33 cases of gastric adenomas and carcinomas originating from the same stomachs were immunohistocnemically investigated for Bcl‐2 protein (Bcl‐2) expression, accumulation of p53 protein and cell proliferation as determined by the KI‐67 labeling index (LI). Bcl‐2 expression was detected in 24/33 (72.7%) adenomas and in 6/33 (18.2%) carcinomas, the difference being statistically significant (P=0.0O01). Only 4 of 33 (12.1%) cases exhibited expression in both adenoma and carcinoma lesions in the same stomachs. ImmunoreactMty was decreased in areas of cellular and structural atypia in adenoma lesions ( P <0.008), and appeared to be positively linked to the tumor progression and the degree of differentatlon in carcinomas, although It did not reach statistical significance. Accumulation of p53 protein was rare In the adenomas but was found in 15/33 (45.5%) of carcinoma lesions, with a significant dissociation from Bcl‐2 immunoreactivity. No apparent relation between Ki‐67 U and either adenoma grading or carcinoma typing was noted, although average KI‐67 LI of the highest labeling areas in carcinomas was statistically higher than in adenomas ( P =0.0001). These results indicate that the regulation of Bcl‐2 expression may differ between gastric adenomas and carcinomas, may be correlated with tumor dlfferentiathre features. In addition, p53 accumulation may play an Important role in the onset of malignancy.