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Comparison of proliferative activities and metastases between two subtypes classified at the deeply infiltrating sites of colorectal moderately differentiated adenocarcinomas
Author(s) -
Taniyama Kiyomi,
Sasaki Naomi,
Wada Shuichi,
Sasaki Masaru,
Miyoshi Nobukazu,
Nakai Hayao,
Kodama Shinya,
Nakatsuka Hirofumi,
Tahara Eiichi
Publication year - 1996
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1996.tb03598.x
Subject(s) - proliferating cell nuclear antigen , pathology , colorectal cancer , lymph node , metastasis , cellular differentiation , cancer cell , biology , immunohistochemistry , proliferation index , cancer , adenocarcinoma , medicine , biochemistry , gene , genetics
Twenty‐eight moderately differentiated adenocarcinomas invading beyond the muscularis propria of the colorectum were subclassified as 13 moderate‐ and 15 poor‐subtype tumors based on the histology at the deeply infiltrating sites. Moderately differentiated cancer cells were correlated with liver metastasis and p53 immunoreactivity. Poorly differentiated cancer cells were correlated with lymph node metastases but not to p53 immunoreactivity. The proliferative cell nuclear antigen (PCNA) labeling index (LI), Ki‐67 LI and agyrophilic nuclear organizer regions (AgNOR) values determined for the poorly differentiated cancer cells in the poor‐subtype tumors were significantly lower than those of moderately differentiated cancer cells in the moderate‐subtype tumors. In cells from tumors classified as poor‐subtype, poor differentiation was associated with decreased PCNA LI levels, but with unchanged Ki‐67 LI and AgNOR values. These results Indicate that colorectal adenocarclnoma cells that are histologically subclassified as moderately differentiated have different proliferative and metastatic activities from cancer cells that are poorly differentiated. Moderately differentiated cancer cells are associated with hematogen‐ous metastasis to liver and high proliferative activity, and loss of tubular formation of cancer cells may be fundamentally related to lymph node metastasis and infittrative growth.