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Basement membrane thickening in the placentae from diabetic women
Author(s) -
Younes Bassam,
BaezGiangreco Atilio,
AlNuaim Lulu,
AlHakeem Amal,
Talib Zeinab Abo
Publication year - 1996
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1996.tb03585.x
Subject(s) - basement membrane , placenta , thickening , lesion , gestation , diabetes mellitus , abnormality , pathology , pregnancy , medicine , biology , anatomy , endocrinology , fetus , chemistry , psychiatry , polymer science , genetics
A light microscopy study was carried out on 48 placentae. Seventeen placentae were obtained from non‐diabetic mothers while the other 31 placentae were from both women with controlled diabetes and women who had an abnormality of the glucose tolerance test. All the women delivered at 38–40 weeks of gestation. Placentae from diabetic patients showed immaturity of the villi, hypertrophy of the capillaries and thickening of the basement membrane of the tropho‐blastJc vllll (3.2 ± 0.35 μm) and the amniotlc membrane (1.8 ±0.3 μm). Focal fibrinold necrosis, an increase in the number of Hofbauer cells and dilatation of villi capillaries were also commonly observed in placentae from diabetic mothers, and the normal cuboidal cells lining the amniotic membrane tended to become tall columnar (17.6 ± 6.3 μm) with distaily located nuciel. Similar findings were observed in patients who had a potentially abnormal glucose toierance test, which suggests the possibility of primary lesion in origin. Therefore, control of hyperglycemia may only partially prevent the development of placental abnormalities.