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Molecular pathogenesis of adenoma and differentiated adenocarcinoma of the stomach
Author(s) -
Tamura Gen
Publication year - 1996
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1996.tb03556.x
Subject(s) - adenoma , loss of heterozygosity , adenocarcinoma , stomach , biology , cancer research , pathology , carcinogenesis , familial adenomatous polyposis , colorectal cancer , cancer , mutation , stomach cancer , medicine , genetics , gene , allele , biochemistry
Advances In molecular biology have revealed a consistent set of genetic aiterations that may correspond to multistep tumor development. The pathogenesis of adenoma and differentiated adenocarcinoma of the stomach are reviewed from a genetic perspective with reference to the colorectal adenoma‐carcinoma sequence. The sequential accumulation of genetic alterations characteristic of the colorectal adenoma‐carclnoma sequence does not occur between sdenoma and differentiated adenocarclnoma of the stomach, although adenomatous polyposis coli (Am) mutation in adenoma, and p53 mutation and loss of heterozygosity (LOH) of DCC (deleted In colorectal cancer) gene in carcinoma are prevalent genetlc alterations. Allelotype, LOH and micro‐satelllte anatyses have revealed several chromosomal regions of ddetlon, as well as genetic Instability, that accumulate during the development and progression of differentiated adenocarcinomas. However, these alterations are rarely found In adenomas of the stomach. These findings suggest that the adenoma‐carcinoma sequence Is relatively rare in gastric carcinogenesis, and that most differentiated adenocarcinomas of the stomach develop through a de novo pathway.