Premium
Nodular pulmonary amyloidosis associated with asbestos exposure
Author(s) -
Hiroshima Kenzo,
Ohwada Hidemi,
Ishibashi Masahiko,
Yamamoto Naoyoshi,
Tamiya Norihisa,
Yamaguchi Yutaka
Publication year - 1996
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1996.tb03535.x
Subject(s) - pathology , asbestos , nodule (geology) , parenchyma , eosinophilic , amyloidosis , lung , medicine , stain , solitary pulmonary nodule , amyloid (mycology) , thoracotomy , anatomy , staining , biology , paleontology , materials science , metallurgy
A 71 year old man was admitted for the purpose of diagnosis of a right solitary pulmonary nodule. The size of the nodule was 18 times 18mm in diameter 2 years ago, but It has become large, 25 times 25 mm In diameter. The nodule was resected by thoracotomy. Microscopically, eosinophilic amorphous, acellular substances were surrounded by inflammatory infiltrates. It stained with Congo red stain and showed green birefringence with polarizing microscopy. Amyloid fibrils were observed electron microscopically. Asbestos bodies were observed in the lung parenchyma around the nodule. This case shows that a nodule in nodular pulmonary amyloidosis can grow gradually and suggests the possibility of asbestos fibers as one of the etiologic factors in nodular pulmonary amyloidosis.