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Mammary hamartoma: immunohistochemical study of two adenolipomas and one variant with cartilage, smooth muscle and myoepithelial proliferation
Author(s) -
Hayashi Hiroyukl,
Ho Takaaki,
Matsushita Kazuhiko,
Kitamura Hitoshi,
Kanisawa Masayoshi
Publication year - 1996
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1996.tb03534.x
Subject(s) - myoepithelial cell , pathology , hamartoma , immunohistochemistry , hyaline cartilage , calcification , cartilage , s100 protein , immunostaining , mammary gland , medicine , anatomy , breast cancer , cancer , alternative medicine , osteoarthritis , articular cartilage
Three cases of mammary hamartoma were investigated Immunohlstochemically and are described. Case 1 was a 42 year old woman with an elastic hard tumor, 1.5 cm in diameter, in her left breast. Case 2 was a 49 year old woman with a semisoft tumor, 5 times 2 cm, in her right breast Case 3 was a 47 year old woman with a hard tumor, 5 cm in diameter, in her left breast. In each case, mammography and ultrasonography revealed a benign‐looking, well‐circumscribed mass without calcification. Histologically, the tumors were composed of adipose tissue, mammary glands, and fibrous and/or fibromuscular tissue. The tumor in case 3 also contained small islands of hyaline cartilage. Immunohistochemical analysis was performed, and epithelial and mesenchymal components were discretely and differentially immunostained except that the smooth muscle component seemed to be derived from myoepithelial cells. Cartilage formation might be the result of metaplasia, and ‘metaplastic variant of the mammary hamartoma’ or ‘choristoma’ may be an appropriate term for cartilage‐containing mammary hamartoma. Using proliferating cell nuclear antigen (PCNA)‐lmmunostaining, we observed that each component of the tumors had an individual growth rate. This finding may reflect one aspect of the biological characteristics of hamartoma.