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Overexpression of p53, c‐ erb B‐2 and epidermal growth factor receptor in human breast carcinomas
Author(s) -
Suzuki Masatsugu,
Okuyama Takazo,
Yoshikawa Kiyotsugu,
Yamaoka Yoshio,
Ariyasu Tetsuya,
Fujita Masayuki,
Tankawa Hidemttsu,
Sugiyama Taketoshi,
Takahashi Rei
Publication year - 1996
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1996.tb03532.x
Subject(s) - immunohistochemistry , grading (engineering) , pathology , epidermal growth factor receptor , lymph node , biology , breast cancer , epidermal growth factor , cancer research , human epidermal growth factor receptor 2 , receptor , cancer , medicine , ecology , biochemistry , genetics
Overexpression of pS3 protein, epidermal growth factor receptor (EGF‐R), and c‐ erb B‐2 protein was assessed by immunohistochemlcai staining of formalin‐fixed, paraffin‐embedded tissue from 64 Invasive breast tumors. The correlation between abnormal expression of each protein and various disease parameters, including lymph node metastasis and histopathologic type and grade was analyzed. Despite the previous proposal, no significant correlation was found between lymph node metastases and overexpression of each gene in the primary tumors. In addition, some metastatic lesions did not always exhibit overexpression, even if it was evident In the primary tumors. Overexpression of c‐ erb B‐2 protein correlated well with Bloom's histological grading. p53 expression was detected most often in tumors with hyperchromatlsm and more frequent mitosis. Over‐expression of c‐ erb B‐2 protein occurred more frequently in p53‐positive tumors. The results Indicate that abnormal expression of p53 protein causes genetic instability in the early stage of tumor development, resulting In subsequent overexpression of other oncogenes.