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Iocalization of Epstein‐Barr virus genome in lymphoid cells in poorly differentiated adenocarcinoma with lymphoid strorna of the colon
Author(s) -
Vilor Mabel,
Tsutsumi Yutaka
Publication year - 1995
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1995.tb03524.x
Subject(s) - biology , lymphatic system , pathology , genome , adenocarcinoma , epstein–barr virus , virus , virology , medicine , cancer , gene , genetics
Poorly differentiated adenocarcinoma with lymphoid stroma occurred in the transverse colon of a 77 year old female. Numerous small lymphocytes and plasma cells were distributed in the tumor stroma. Non‐isotopic in situ hybridization study for Epstein‐Barr (EBV)‐related small nuclear RNA (EBER‐1) revealed positive signals in the nuclei of a few lymphocytes in the tumor stroma, while the tumor cell nuclei were not labeled. lrnmunostaining for latent membrane protein‐1 was negative. The significance of detection of the EBV‐infected lymphocytes in the colon tumor strorna is discussed.