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Small cell neuroendocrine carcinoma of the rectum
Author(s) -
Vilor Mabel,
Tsutsumi Yutaka,
Osamura R. Yoshiyuki,
Tokunaga Nobuhiro,
Soeda Jinichi,
Ohta Masatoshi,
Nakazaki Hisao,
Shibayama Yasuhisa,
Ueno Fumiake
Publication year - 1995
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1995.tb03510.x
Subject(s) - rectum , synaptophysin , pathology , malignancy , adenocarcinoma , metastasis , small cell carcinoma , medicine , chromogranin a , carcinoma , neuroendocrine differentiation , biology , immunohistochemistry , cancer , prostate cancer
Poorly differentiated small cell neuroendocrine (NE) carcinoma of the colon and rectum is a rare primaty epithelial malignancy at this location. A case of a highly aggressive NE tumor of small cell type, combined with non‐invasive well‐differentiated papillary adenocarcinoma in villous adenoma is reported. The patient died rapidly with massive and progressive liver metastasis. The tumor cells were argyrophilic and diffusely immunoreactive for neuron‐specific enolase and synaptophysin. Ultrastructural analysis disclosed NE‐type cored granules in most of the small tumor cells. NE tumors of the colon and rectum are briefly reviewed.