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Intercellular adhesion molecule‐1 expression by macrophages in human gastrointestinal carcinoma: Possible roles as host immune/inflammatory reaction
Author(s) -
Mizoi Takayuki,
Ohtani Haruo,
Suzuki Yukimasa,
Shiiba Ken'ichi,
Matsuno Seiki,
Nagura Hiroshi
Publication year - 1995
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1995.tb03504.x
Subject(s) - stromal cell , immunoelectron microscopy , biology , pathology , intercellular adhesion molecule 1 , endoplasmic reticulum , immune system , macrophage , inflammation , lymphocyte , stroma , intercellular adhesion molecule , cell adhesion molecule , immunohistochemistry , microbiology and biotechnology , cell adhesion , cancer research , cell , immunology , medicine , in vitro , biochemistry , genetics
Tumor‐associated macrophages (TAM) are one of the factors which modulate the carcinoma progression. The present study described immunohistochemical expression of intercellular adhesion molecule‐1 (ICAM‐1) in stromal cells in human gastrointestinal carcinoma identifying the cell types by immunoelectron microscopy. In colon and gastric carcinomas, ICAM‐1‐positive cells were mostly stromal cells, and major cell types were identified as macrophages and fibroblasts by immunoelectron microscopy. Macrophages were characterized by their ovoid shape, cytoplasmic projections, abundant vacuoles, phagocytosis, and paucity of rough endoplasmic reticulum. Fibroblasts contained stacks of rough endoplasmic reticulum. Macrophages were major cells among ICAM‐1‐positive cells along the invasive margin, while fibroblasts were predominant in the stroma within carcinoma in colon and intestinal‐type gastric carcinomas. Lymphocytes positive for lymphocyte function associated antigen (LFA‐1), a counter‐receptor of ICAM‐1, were densely distributed along the invasive margin, and sparsely in the stroma within carcinoma. In diffuse‐type gastric carcinoma, most macrophages were dendriticshaped and negative for ICAM‐1. Our study suggests that the invasive margin is an area similar to active inflammation, where the antigen presenting cells (macrophages) and lymphocytes may interact via the ICAM‐1/LFA‐1 adhesion.