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Pulmonary tumor thrombotic microangiopathy
Author(s) -
Sato Yuichiro,
Marutsuka Kousuke,
Asada Yujiro,
Yamada Manabu,
Setoguchi Toshiaki,
Sumiyoshi Akinobu
Publication year - 1995
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1995.tb03481.x
Subject(s) - thrombotic microangiopathy , medicine , pathology , differential diagnosis , adenocarcinoma , pulmonary hypertension , cancer , microangiopathy , intimal hyperplasia , radiology , smooth muscle , diabetes mellitus , disease , endocrinology
Pulmonary tumor thrombotic microangiopathy (PTTM) is characterized by widespread fibrocellular intimal proliferation of the small pulmonary arteries and arterioles in patients with metastatic Carcinoma. Microscopic pulmonary tumor emboll have frequently occurred in patients with malignant tumors; however, few cases of PTTM have been reported. A rare case of a patient with gastric adenocarcinoma who presented with acute dyspnea and lethal respiratory failure is described. Histologically, diffuse fibromuscular intimal thickening cauring luminal stenosis and obstruction but containing rather few cancer cells was observed in the small pulmonary arteries and arterioles. These findings were consistent with PTTM. Atthough PTTM is a rare phenomenon, PTTM should be considered in the differential diagnosis of acute dyspnea or pulmonary hypertension in patients with carcinoma.