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Aneryhremic form of acute erythremic myelosis (Di Guglielmo's syndrome) causing hepatosplenomegaly due to the infiltration of hemoglobin‐bearing blast cells: An autopsy case
Author(s) -
Tsuji Motomu,
Tamai Masamltru,
Terada Nobuyuki,
Tako Hajime
Publication year - 1995
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1995.tb03462.x
Subject(s) - hepatosplenomegaly , pathology , medicine , autopsy , infiltration (hvac) , disease , physics , thermodynamics
An autopsy case of a 42 year old man with the anerythremic form of acute erythremic myelosis (Di Guglielmo's syndrome) is reported. The patient was admitted because of a 1 month history of fatigue and fever. Physical examination showed hepatosplenomegaly. Laboratory data showed leu‐kopenla, mild normocytic anemia, and high levels of serum lactate dehydrogenase and vitamin B12. Bone marrow aspirate revealed an elevated number of erythroblasts, with dyserythropoiesis (E/M=3.7). After admission, thrombocy‐topenla progressed rapidly, but blast cells were not seen in the peripheral blood throughout the clinical course. On the Wh hospttal day, the patient died of pneumonia. At autopsy, the spleen welghatd 550 g and the liver 1800 g. Histologically, the white and red pulps of the spleen and the portal region and sinusoid of the liver were diffusely infiltrated by blast cells that were positive for anti‐hemoglobin (Hb) antibody on immunoperoxfdase staining. The bone marrow, the lymph nodes, the adrenal glands, the pancreas, and the heart were also infiltrated by the blast cells. This was thus considered to be a rare case of the anerythremic form of acute erythremic myelosis (Di Guglielmo's syndrome), the findings showing that Hb immunoperoxidase staining is useful for the diagnosis of this condition.