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Mueinous cholangiacarcinoma featuring a unique microcystic appearance
Author(s) -
Sonobe Hlrashi,
Enzan Hideaki,
Ido Eiji,
Furihata Mutsuo,
Iwata Jun,
Ohtsuki Yuji,
Watanabe Ryohei
Publication year - 1995
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1995.tb03459.x
Subject(s) - pathology , lesion , medicine , autopsy , stroma , parenchyma , anatomy , immunohistochemistry
An autopsy case is presented of a peculiar type of intrahe‐patic mucinous adenocarcinoma with microcyst formation arising In a 78 year old Japanese man who died of hepatic coma and renal failure 4 months after onset. Macroscopi‐cally, the cut surface of the lesion revealed a characteristic honeycomb‐like appearance, consisting purely of micro‐cysts, 0.2–0.4 cm in diameter, lined by prolific mucin‐producing adenocarclnoma cells. The lesion did not have large cystic space, flbrous capsule, or benign cystadenoma‐tous component other than neoplastic microcyst formation. The carcinoma cells showed various proliferating patterns, such as irregularly shaped nest‐like, trabecular, papillary and tubular ones, directly Invaded the hepatic parenchyma and portal tract with loose or thick fibrosis, and infiltrated extensively into both intrahepatic and extrahepatic stroma along the vascular structures. From these clinicopathologi‐cal ffndlngs, we conslder the present tumor to be a variant of mucinous cholangiocarcinoma with characteristic microcyst formation rather than a type of cystadenocarcinoma.